F8259
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F8259
Sigma
Folinic acid calcium salt hydrate
powder, cell culture tested
| Synonym: | 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl- |
| CAS Number: | 1492-18-8 (anhydrous) |
| Linear Formula: | C20H21CaN7O7 · xH2O |
| Molecular Weight: | 511.50 (anhydrous basis) |
| Beilstein Registry Number: | 5723924 |
Description
| Application | Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer. |
Properties
| assay | ≥90% |
| form | powder |
| suitability | cell culture tested |
Safety
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42/43 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
Related Products
| Replaced by | F7878, Folinic acid calcium salt hydrate |
